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Name: glp-1/gip dual agonist weight loss GIPR/GLP-1R therapies for diabetes and loss—chemistry, physiology, and clinical applications: Cell Metabolism When the Breakthrough Obesity G-Agonist
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Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis

Additionally, isotope tracing studies have demonstrated that lactate functions as a major fuel in the TCA cycle, where 13C-lactate labeled TCA intermediates in every tissue of the body, even in tumors (31,32)

This can happen gradually, so you may not notice the signs right away