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Appl Environ Microbiol 58:832839

A diagnosis of 5-oxoprolinemia should be considered in any patient with unexplained metabolic acidosis and a history of therapeutic acetaminophen dosing, particularly those patients with coexisting conditions that may decrease the glutathione stores

Neuroscience IGF-1R is strongly expressed in developing and adult brain

However, it is relevant context for any researcher evaluating the HGF/c-Met pathway as a research target for cognitive applications the pathway has not yielded a successful clinical readout for a related modulator molecule to date

Novakova K, Kummer O, Bouitbir J, Stoffel SD, Hoerler-Koerner U, Bodmer M, Roberts P, Urwyler A, Ehrsam R, Krahenbuhl S