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In humans, GH secretion during early sleep may be nearly totally suppressed by administration of a specific GHRH antagonist ( Growth hormone injections are traditionally timed to align with the natural circadian rhythms of GH secretion, typically during the early night, to coincide with the onset of slow-wave sleep ( We hypothesized that daily GH injections given in the evening could disrupt sleep both by inhibiting GHRH secretion, and due to the discomfort and psychological distress associated with the injection and local reactions

This process also influences insulin-like growth factor (IGF-1) production in the liver, a key mediator of growth hormones effects on the body

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Compared to natural ligands, retatrutide shows lower potency at GLP-1 and glucagon receptors but higher potency at GIP receptors