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Another possibility is the following: after uptake, vitamin B12 is slowly bound to serum vitamin B12 proteins ( The mechanism by which vitamin B12 administration exerts its positive effect on ME/CFS patients is unknown

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What does nitric oxide (NO) pathway mean, and why is it mentioned

The conservative approach involves cycling use (4-12 weeks on, 4-6 weeks off) to prevent potential receptor downregulation and maintain effectiveness

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