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Indeed, exenatide treatment decreased bone marrow hematopoietic stem and progenitor cell proliferation in Ldlr / mice on HFD (8) and in wild-type mice exposed to chronic-restrain stress (19)

9 Tirzepatide is also superior to semaglutide on weight: on average, patients had a -20% drop in body weight by 72 weeks on tirzepatide compared to -13% on semaglutide

A 2014 FDA and European Medicines Agency (EMA) joint analysis found similar rates of pancreatic cancer between GLP-1-treated patients and comparators, though absolute event numbers were small

on the other hand, surfactant protein A is the most prevalent protein in PS

All these contribute to reduced insulin sensitivity, IR, compensatory hyperinsulinaemia, metabolic abnormalities, and eventually T2D, creating a vicious cycle of feed-forward effect [1922]