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In a similar way, treatment with the anti-programmed death 1 receptor monoclonal antibody pembrolizumab interfered with thyroid function causing elevation of anti-thyroid antibodies accompanied by AITDs resulting in either hypo- or hyperthyroidism (66)

Mousavi F, Eidi A, Khalili M, Roghani M

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The Cterminal amide group minimizes rapid degradation, making the peptide stable during storage and experimental procedures used in analytical and molecular studies