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In 2023, the FDA placed several peptides including CJC-1295 on its list of bulk drug substances that may not be used in compounding, citing a lack of clinical evidence of safety and effectiveness

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GLP-1Rs are widely expressed in areas of the mesolimbic reward pathway that receive direct projections from the nucleus tractus solitarius (NTS) (Alhadeff et al., 2012)

Increased caffeine consumption: Some people use black coffee or green tea to suppress appetite, and caffeine is a known stimulant of gut motility

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