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"Once-Weekly Semaglutide in Adults with Overweight or Obesity." N Engl J Med

Last reviewed: June 25, 2026 Last updated: June 25, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Lifestyle factors influence outcomes significantly

Extended escalation for sensitive individuals If standard 4-week intervals produce intolerable side effects, extending each phase to 6 or 8 weeks is a reasonable modification

Switching to tirzepatide sometimes produces a stronger response because it activates both GIP and GLP-1 receptors