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While the presence of PSS around the lid/active site of Regucalcin homologs suggests a possible effect on the modulation of its gluconolactonase activity, clusters of PSS located elsewhere suggest a possible effect on the modulation of the interaction strength between Regucalcin and its interactors

However, a higher risk of diabetic ketoacidosis is observed with SGLT2 inhibitors

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Chronic low-dose exposure models that more closely mimic environmental and human exposure scenarios will be essential for understanding long-term biological consequences