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The Saxagliptin Assessment of Vascular Outcomes (SAVOR-TIMI 53) study is a similar study in 12,000 patients comparing saxagliptin with placebo in diabetic patients with high cardiovascular risk

GLP-1 agonists work through distinct mechanismsenhancing glucose-dependent insulin secretion, suppressing glucagon, delaying gastric emptying, and promoting central satiety signaling

Cortisol directly impairs insulin signaling pathways that overlap with GLP-1 receptor cascades

Finally, tirzepatide was associated with significantly reduced occurrence of a composite kidney outcome comprising new-onset MA, 40% eGFR decline, end-stage renal disease and death due to kidney failure (HR 0.58, 95% CI 0.430.80) [49]

It also controls appetite by regulating stomach emptying and our subjective experience of fullness via the brain