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Anti-Oxidative Stress GLP-1 agonists reduce reactive oxygen species (ROS) and upregulate antioxidant enzymes, protecting neurons from ischemic damage [13]

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Subsequent assay studies indicated that (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl) butan-1-one (40) possesses strong in vitro activity, favorable selectivity, and in vivo efficacy in mouse models (Figure 6)