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Similarly, headaches occurring with signs of hypoglycemia (shakiness, sweating, rapid heartbeat, confusion) require prompt attention, particularly in patients taking insulin or sulfonylureas in addition to semaglutide, as dose adjustments of these medications may be necessary

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MOH could be stratified into simple and complex phenotypes according to different clinical parameters (i.e., amounts and class of analgesics, psychiatric comorbidities, history of relapse after withdrawal, symptoms of central sensitization and maladaptive anticipatory response to pain experience)