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Currently, tirzepatide is the clear choice for type 2 diabetes because it has FDA approval for this indication and extensive clinical evidence

Oral Wegovy uses a higher 25 mg dose specifically optimized for obesity

found that the transcription factor ChREBP can also promote BCKDK and inhibit PPM1K expression to inhibit BCKDH activation and promote ATP citrate lyase (ACLY) activation, upregulate the lipid synthesis pathway, and induce hepatic steatosis in the obesity model of high-sugar diet

doi: 10.3390/healthcare8030211 40 WilliamsLRIsaacson-BarashC

The number that built a decade of demand was a quote in a university news item, not a line in a methods section