Who Should Not Use GLP-1 Medications According to standard clinical guidelines and prescribing information, GLP-1 medications may not be appropriate for individuals who: Have a personal or family history of medullary thyroid carcinoma Have multiple endocrine neoplasia syndrome type 2 Have a history of pancreatitis Have severe gastrointestinal disease (gastroparesis, inflammatory bowel disease) Are pregnant, planning to become pregnant, or breastfeeding Have a history of severe allergic reactions to semaglutide, tirzepatide, or any inactive ingredients This is not a replacement for prescribed medical treatment for any health condition
You prefer a daily routine: Some patients find it easier to remember a daily habit (like brushing teeth) than a weekly task that can be forgotten in the hustle of a busy schedule
Only increase if weight loss stalls for 3 or more consecutive weeks, appetite suppression fades before your next injection, or your prescriber recommends escalation based on your individual progress
The character of the GI side effects differs between the two medications
People who experience nausea may also drink less, which adds to the problem