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circRNAs have been reported to involve in the pathogenesis of some autoimmune diseases and have a wide range of functions, such as RNA polymerase (RNAP) II elongation, miRNA and RBP sponge, RNA maturation regulation, protein localization, and so on (290)

One aspect of the embodiments disclosed herein is to provide a controlled release composition or formulation for the treatment of fluid homeostasis disorders