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The physiological differences between models and human disease constitute a significant obstacle in current research, also complicating the interpretation of cross-model comparison results

MAFLD is characterized by the abnormal accumulation of fat (steatosis) in the liver in the absence of heavy alcohol consumption and in the presence of obesity, type 2 diabetes mellitus, or metabolic dysregulation (92)

Food Microbiology, 35 , 9298

The MGBA thus offers a multimodal therapeutic target: unlike a drug that hits one receptor, manipulating the gut can simultaneously affect numerous pathways (immune, metabolic, etc.) that are dysregulated in NDDs

These results demonstrate that import of L-cystine from system x c - , but not export of L-glutamate, regulates glucose deprivation-induced cell death