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The study was reviewed and approved by the IRB of the Korea Brain Research Institute and KNUH (IRB File No

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Notably, a small cell lung carcinoma cell line, which expresses POMC and ACTH, possesses a hypomethylated POMC promoter, suggesting that ectopic ACTH secretion by tumors may be due to hypomethylation at a relatively early stage in carcinogenesis (41)

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Chalcones have shown potential effectiveness against both drug-susceptible and drug-resistant cancers, making them promising candidates for the development of new antitumor agents (94, 126)