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For such a switch, its common to receive a gradual transition plan in order to minimize side effects
As compared to placebo, all doses of tirzepatide and semaglutide increased risk for gastrointestinal adverse events, with tirzepatide 15mg yielding the highest increased risk (3.6 times) for nausea, vomiting (4.4 times) and diarrhoea (double the risk)
WalshAM, CrispieF, KilcawleyK, OSullivanO, OSullivanMG, & ClaessonMJ (2016)
It names untreated hypothyroidism and uncontrolled hyperthyroidism as requiring caution, arguing that starting tirzepatide before thyroid function is optimized risks compounding fatigue, weight-gain resistance, and metabolic dysregulation
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