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PI3K signalling is required for leptin effects in the hypothalamus, and a dysfunctional pathway contributes to leptin resistance during diet-induced obesity

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Stress Suppresses GLP-1 (The Cortisol Cravings Loop) Cortisol decreases natural GLP-1 by: reducing SCFA-producing bacteria increasing inflammation flattening the circadian rhythm damaging mucosal integrity destabilizing serotonin and appetite signals This leads to: Stress cortisol low GLP-1 cravings overeating belly fat Reference Stress & Eating Behavior (Annual Review of Psychology, 2019) 7

In the first case, we had neonatal hyperinsulinism due to isolated high maternal sugar intake, an event that has never been reported in the literature

GHK-Cu combines the tripeptide glycyl-l-histidyl-lysine (GHK) and copper (Cu)