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In a UUO mouse model of kidney fibrosis, administration of 300 g/kg recombinant human BMP-7 inhibited SMAD3 and Akt activation while increasing expression of the phosphatase and tensin homolog (PTEN) resulting in attenuation of fibrogenesis [78]
[22,53] Notably, oral administration of different forms of pCons peptide, including D and L forms, delayed anti-ds-DNA Ab production and lupus nephritis, and increased the survival of lupus mice
However, the clinical application of lactylation modifications requires further investigation to ensure their efficacy and safety
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