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By contrast, ICA exerted no protective effect in GPX4-silenced SW1353 cells, indicating that the drug ameliorates ferroptosis and cartilage injury via the SLC7A11/GPX4 pathway (153)

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However, at 24 h, real-time cell migration assays showed a slow release of curcumin and lower activity

GSH was shown to be the main inhibitor in the active site of the main protease (M pro ), the essential protein for virus invasion, and cysteine (Cys300) glutathionylation inhibits M pro activity by blocking its dimerization supporting the use of GSH in COVID-19 patients (Davis et al., 2021