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GLP-1 is an incretin hormone secreted by L-cells in the small intestine in response to nutrient intake

Unlike semaglutie, which only targets GLP-1, tirzepatide targets both GLP-1 and GIP, which may make it more effective for weight loss while also reducing side effects

Investigators studying combined-compound protocols often cite this non-overlap as the rationale for blend formats each compound contributes activity at a distinct molecular target without competing for the same receptor or downstream effector

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On the other hand, by maintaining elevated GH levels over an extended period, CJC 1295 enhances the utilization of stored fat for energy