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Most notice appetite changes by week 3-4 and average 24.2% weight loss by week 48

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Theres a lot of people who just get these things and shoot them, Marco, a retatrutide user who has bought the drug from what he considers trusted sources, told The Atlantic

Rapid weight loss, a primary effect of the medication, can alter biomechanics and joint loading patterns, potentially causing musculoskeletal discomfort during the adaptation period