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Retatrutide requires up to 17 separate purification steps during synthesis, compared to only 9 steps for basic semaglutide

doi: 10.1038/s41584-024-01158-w 287 JiangXStockwellBRConradM

The analysis ranked the compound at the upper end of effect-size estimates within its drug-class neighbourhood and noted the limited number of head-to-head studies at this writing

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Their activity is assessed through broth microdilution assays to identify their Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) and antibiofilm assays and the mechanism of action against Candida strains gauge their efficacy against candidal infections