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Grad, L.I

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The team explored several pathways, including the PI3K/Akt pathway, which affects pancreatic duodenal homeobox 1 (PDX1) and Forkhead box O1 (FoxO1) transcription factors, essential for cell proliferation

Breast Cancer Previous cell-based and human studies have indicated that sulforaphane exposure is associated with decreased breast cancer progression, including initiating cell cycle arrest and apoptosis ( There are limited human studies that have evaluated the role of sulforaphane on breast cancer

As a positive control for apoptosis, tamoxifen (50 M) was included (Mandlekar and Kong, 2001)