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The accumulated ROS in cells interacts with Ca 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload (91)

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This serious side effect, highlighted through case studies, emphasizes the need for caution and further research into Melanotan II's impact on kidney function and overall safety profile

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