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The treatment of T2D has shifted from a gluco-centric approach to a broader cardio-renal-metabolic strategy, emphasizing the prevention of cardiovascular and renal events and the improvement of metabolic aspects beyond glucose control such as promoting weight loss

While adenosine triphosphate (ATP) signaling was enhanced in cultured DRG neurons treated with exendin-4, capsaicin sensitivity and calcium influx remained unaffected, suggesting GLP-1R predominantly modulating gut motility rather than pain signaling [55]

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In a Japanese comparative study of these agents used at different doses, HbA1c-lowering effects after 52 weeks of treatment were greater with dulaglutide (up to 0.75 mg/week) than liraglutide (up to 0.9 mg/day) 12

As TGs accumulate in the circulation after tyloxapol injection, these experiments were terminal, and mice were sacrificed after the 3-hour time point