The meniscus performs several vital functions, including: Shock Absorption: The meniscus helps absorb the impact during activities such as running and jumping
[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Guan S., et al
The caveat here is the one that recurs throughout translational medicine: mechanistic plausibility and animal efficacy do not guarantee that the same advantage materializes, or is well tolerated, in humans
Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC (1983) Exon duplication and divergence in the human preproglucagon gene
The Commissions definition of clinical obesity, and making this population the main focus for AOM use, broadly aligns with how publicly funded health systems already think about prioritising AOM reimbursement, e.g., NICE guidance defining eligibility for treatment with semaglutide and tirzepatide using a BMI cut-off plus presence of a co-morbidity, or Medicare Part D coverage of AOMs with medically accepted indications, such as diabetes or reducing the risk of major adverse cardiovascular events in patients with established cardiovascular disease
