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QA accumulation is associated with brain inflammation and cell death, and patients with advanced CKD exhibit elevated plasma KYN metabolites and QA, which uniquely correlate with fatigue and reduced quality of life (Saliba et al., 2024), supporting the role of gut-derived KYN metabolites in linking CKD to neuroinflammation

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L-theanine can increase the activity of antioxidant enzymes in piglets, reduce the MDA content in jejunal mucosa, and alleviate hydrogen peroxide-induced intestinal cell damage in piglets by activating the Nrf2 signaling pathway and reducing keap1 expression [142,147]

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Mucin on the amphibian skin surface likely stimulates the waterborne zoospores to recognise the host and encyst (17)