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Exercise caused a similar increase in infiltrating macrophages in both groups

2025 Impact of transfusion dependent alpha- and beta-thalassemia on adult patients health-related quality of life and work productivity: A multi-region real-world survey Janet Kwiatkowski 1 , Khaled Musallam 2 , Maria Domenica Cappellini 3 , Christina Chamberlain 4 , Amey Rane 4 , Keely Gilroy 4 , Susan Morris 4 , Emma Chatterton 5 , Brianne Kerr 5 , Katie Lewis 5 , Ali Taher 6 1 Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, 2 Burjeel Medical City, Abu Dhabi, United Arab Emirates, 3 Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy, 4 Agios Pharmaceuticals, Cambridge, Massachusetts, USA, 5 Adelphi Real World, Bollington, UK, 6 American University of Beirut Medical Centre, Beirut, Lebanon Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2025 Aims Research on the impact of transfusion-dependent thalassemia (TDT) on health-related quality of life (HRQoL) and work productivity is limited, particularly in -TDT

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These pathologies are mediated by microbial metabolites, such as SCFAs, microbial endotoxins, and others, that neurologically act on human brain health directly and indirectly

Results at the 36 mg dose which became the target dose for Phase 3 showed: - Mean body weight loss: 14.7% - Participants losing 10% or more: approximately 67% - Participants losing 15% or more: approximately 46% The Phase 3 ACHIEVE program extends the treatment duration to 72 weeks with larger sample sizes