5 In addi- tion to their insulinotropic effect, incretin mimetics have demonstrated positive effects on pancreatic -cell function and proliferation, decreased body weight, plasma lipid prole, and blood pressure
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Understanding these genetic factors can support a provider conversation about realistic expectations, potential dose requirements, and whether GLP-1 is a good fit alongside other lifestyle modifications or complementary approaches
This concept, referred to as biased agonism or signal bias, is defined by ligands of the same receptor that show favoured and distinct coupling preferences to particular cellular effectors or pathways (7)
10.1111/j.1471-4159.2004.02584.x J Neurochem