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However, challenges such as gastrointestinal side effects and high medication costs are limiting broader accessibility

Mistake 6: Stopping fiber during side effect flares When GLP-1 side effects intensify, especially after dose increases, many users stop all supplements including fiber

For broader questions about how safe these medications are in general, the SELECT trial data, and what the 2024 to 2026 evidence shows on the most-discussed concerns, see our separate guide on whether weight-loss injections are safe

They are not recommended during breast-feeding

One in five adults has taken a GLP-1 drug at some point, according to a November 2025 poll from health-care think tank KFF