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2020 doi: 10.1101/2020.02.27.967588

Beyond lipid enzymes and microRNAs, exosomes derived from ferroptotic neurons also carry immunogenic DAMPs, which can be internalized by both microglia and astrocytes, triggering their innate immune recognition systems and initiating secondary immune responses

FSP1 can inhibit ferroptosis by reducing ubiquinone or CoQ to ubiquinone or CoQH 2 on the cell membrane, with the latter functioning as an antioxidant that trap radicals and thus prevents lipid peroxidation, thereby preventing ferroptosis (Fig

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In particular, one study examined the association between CKD and homocysteine levels in the context of genetic patterns and found that homocysteine was likely to play a causative role in CKD