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Similarly, TB-500 has undergone extensive safety evaluation including human research trials showing safety at intravenous doses up to 1,260 mg equivalent, with no dose-limiting toxicities or serious adverse events attributable to the peptide in carefully controlled studies

Discontinuation of GLP-1 RAs outside of pregnancy is known to cause weight regain and worsening hyperglycemia

Medication costs are determined separately by licensed pharmacies

276 The number 7.4 million for 2026 comes from a linear extrapolation of the reported projections for 2025 (7.16) and 2030 (8.53) in the CHAP study

Baseline Characteristics in Adults Patients with Noncirrhotic MASH with Stage 2 to Stage 3 Fibrosis in Study 11 a Less than 5% missingness in the variable is omitted