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Indeed, c-myc induces the transcription of glutamine transporters, such as SLC1A5/ASCT2, and also promotes the expression of glutamine-catabolized enzymes such as glutaminase 1 (GLS1) and carbamoyl-phosphate synthetase 2 - aspartate transcarbamylase - dihydroorotase (CAD), in order to encourage glutamine uptake by converting glutamine to glutamate [19-21]

The metal-binding affinities of the individual Cu(II) proteins, determined by different methods vary largely as their accurate estimation is a subject to a number of pitfalls and complicating factors 29

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Nat Med (2015) 21(1):2736