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Here are some significant clinical trials that give evidence for semaglutide's long-term weight loss benefits: Semaglutide Treatment Effect in People with Obesity (STEP) Trials : The STEP program consisted of four phase 3 clinical trials (STEP 1, STEP 2, STEP 3, and STEP 4) that evaluated the efficacy and safety of semaglutide for weight management

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It also may include: Watching you walk with and without shoes on