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Michael White, head of the department of pharmacy practice at the University of Connecticut, tells TODAY.com

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The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7

Patients should seek urgent care for symptoms such as severe stomach pain, signs of pancreatitis, trouble swallowing, persistent hoarseness, a neck lump, yellowing of the skin or eyes, dark urine, or difficulty breathing

Yes, B12 injections are generally considered very safe with minimal side effects