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For countless women, lipedema causes daily discomfort and emotional distress that standard diets and intensive exercise simply cannot fix

According to NICE guidance (NG28), treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on dual therapy

doi: 10.1152/physrev.00035.2017 407 MurrayKBarbozaMRudeKMBrust-MascherIReardonC

Switching of modA expression from OFF to ON state within the middle ear produces a phenotypic switch in several genes during infection that increases disease severity and permits bacterial persistence by increasing cell adhesion, invasion and robust biofilm formation ( ModA16 ON state, NTHi upregulates multiple iron-acquisition factors including an iron ABC transporter substrate-binding protein, and haem/haemopexin-binding proteins HxuC and HxuB (Tram et al., 2024)

These findings reinforce the strength of LVAD therapy as a life-sustaining option for younger patients