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Also, circulating IGF-I deficiency due to hepatic under-insulinization in type 1 diabetes is associated with low GHBP levels

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Wang H, Wang L, Li Y, Luo S, Ye J, Lu Z, et al

[8] As a result of these potential interactions, GHRP-2 has been observed to apparently lead to a 47-fold increase in pulsatile GH secretion, while GHRH-mimetics appear to lead to only a 20-fold increase

Discussion Compared to individual parameters, composite biomarkers may provide a more robust method for evaluating disease progression in response to a study intervention than a single efficacy outcome [28]