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On the basis of the complex physiopathology of these pigmentary disorders, various treatment solutions are envisaged alone or in combination and summarized in Fig

These developments are consistent with the evolving understanding of the gastrointestinal tract as a key endocrine organ that regulates appetite, glucose homeostasis, energy expenditure, and gastrointestinal motility through a complex network of hormonal signals [20]

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It transforms a potential point of failure into a reliable, repeatable scientific procedure