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The trans-3-hexenoic acid modification improves resistance to DPP-IV cleavage, extending peptide stability and supporting a more favorable pharmacokinetic profile than native GHRH

doi: 10.1016/j.tice.2025.102837

Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency