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Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease

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These data are in agreement with the well-described association of macrophage-dependent chronic AT inflammation with systemic insulin resistance and with genetic knock out of key inflammatory signalling molecules, scaffolding proteins, or cytokines sufficient to dissociate obesity from insulin resistance 59,60,61,62,63,64,65,66

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