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At 1 year, the group had a mean BMI of 27.9 kg/m 2 and had lost approximately 18.3% (95% CI, 13-23.6) of their body weight from baseline

348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5