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hospitals, practices, or providers who voluntarily opt in would likely differ from those who do not opt in in important but unobservable ways and would therefore undermine the comparability between the intervention and comparison groups, which would weaken the model evaluation

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At normal blood glucose levels, up to 97% of glucose filtered by the glomeruli is reabsorbed by sodium-dependent glucose transporter-2 (SGLT2) in the initial segment of the tubule, and only 3% of the remaining glucose is reabsorbed by sodium-dependent glucose transporter-1 (SGLT1) in the later segment of the proximal tubule (17)