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Importantly, LPAR1-transduced LPA signaling promotes AR nuclear localization, with proliferative effects inhibitable by the antiandrogen bicalutamide, indicating LPA-AR pathway synergypartially explaining traditional AR-targeted therapy failure in CRPC

The 7TM domain comprises seven -helices (TM1-TM7) separated by three intracellular loops (ICL1-ICL3) and three extracellular loops (ECL1-ECL3), with an additional intracellular C-terminal domain

Synthetic tetrapeptide Epitalon restores disturbed neuroendocrine regulation in senescent monkeys

The current recommendations are to consider hemodialysis in adults from a cut-off at 200 g/dl