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While the low number of events of cholangiocarcinoma in clinical trials precludes informative analyses [9,10,11,12,13,14], this safety signal is currently being monitored by the European Medicines Agency [15, 16]

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The cross-sectional design is a natural limitation making it impossible to determine causal relationships when evaluating the associations

SYMLIN administered subcutaneously immediately prior to a meal reduced plasma glucose concentrations following the meal when used with mealtime insulin (rapid-acting insulin analogs or regular human insulin) (Figure 2)

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