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Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

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The gap between clinical trial efficacy and real-world effectiveness represents an important consideration for healthcare providers and patients

Median progression-free survival for Keytruda plus Padcev was 12.5 months compared to 6.3 months for chemo alone

Bourla likened the opportunity to Pfizer's experience with Viagra, which the company launched in 1998