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Higher concentration of cytokines leads to the dysfunction of the cells at an early stage of chronic pancreatitis [61]

Notably, elevated levels of SCFAs enhance glucose management through processes such as activation of intestinal gluconeogenesis and increased GLP-1 secretion, this promotes metabolic benefits in terms of energy balance ( Bacteroides fragilis , a bacterium that suppresses bile salt hydrolase activity, leading to a rise in secondary bile acids like GUDCA

Familial predisposition is the most important risk factor for melasma, and nearly 300 genes have been identified to be differentially expressed in the skin lesions of melasma

Some research has explored berberine's relationship with incretin hormones

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