There is actually a direct effect on the brain chemistry somehow, where they are just almost feeling like they're in a brain fog, just chronically fatigued on the medication
Oyedeji AA, Owoleke A V, Oku IY, Ojo OI, Angaye TCN, Komolafe T
The authors of the study wrote that the potential mechanisms behind these effects include "L-carnitine's role in transporting fatty acids across mitochondrial membranes, enhancing beta-oxidation, reducing free fatty acid availability, and inhibiting cholesterol synthesis." In addition, the authors noted, "L-carnitine exhibits antioxidant and anti-inflammatory properties, which can further modulate dyslipidaemia (the imbalance in blood lipids) and protect LDL from oxidative stress." Finally, it was reported that L-carnitine was able to reduce the conversion of free fatty acids to triglycerides, and ultimately prevent the build-up of triglycerides
The medication does not directly increase metabolic rate or preferentially promote fat burning
Reddit reviews are more mixed