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Oralrespiratory axis Although oral microorganisms can also influence respiratory health through systemic routesincluding LPS dissemination, outer membrane vesicles, and pro-inflammatory cytokines entering the circulationthe defining feature of the oralrespiratory axis is the direct physical translocation of oral microbiota into the lower airways via microaspiration 192

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Our recent meta-analysis study showed that low-dose melatonin ( 1 mg) may be more effective at initiating sleep [84]